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Natural Health Centre

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Herbal medications and drug interactions

It is often thought that herbal supplements are safe because they are derived from natural sources and have been used for thousands of years. However, many herbal medications contain active ingredients that can interact with other medications you may be taking. Just as prescription medications can interact with one another, herbal supplements may also mimic, increase, or decrease the effect of your medications, possibly causing serious harm.

Which medications interact with herbal supplements?

If you are currently taking any of the following types of medications, speak to your doctor or Shoppers Drug Mart Pharmacist before starting any herbal supplements:

  • antidepressants (e.g., monoamine oxidase inhibitors such as phenelzine or tranylcypromine)
  • blood pressure medications
  • blood thinners (e.g., aspirin, warfarin)
  • diabetes medications
  • medications that affect the liver (check with your pharmacist to see if your medications could affect your liver)
  • heart medications
  • HIV medications
  • transplant medications

Which supplements should be avoided if you are taking medications?

Most herbal supplements have the potential to interact with your medications, especially the following, which can produce harmful side effects:

  • black cohosh
  • cayenne
  • dong quai
  • ephedra (ma huang)
  • feverfew
  • garlic
  • ginger
  • ginkgo
  • ginseng
  • goldenseal
  • kava
  • licorice root
  • milk thistle
  • Scotch broom
  • St. John's wort
  • valerian

Other herbal medications not listed here may also interact with your medications. Check with your Shoppers Drug Mart Pharmacist before starting a new herbal supplement.

Popular herbal supplements and interactions

St. John's wort is marketed as a treatment for mild to moderate depression. It is a popular alternative to traditional antidepressants because it lacks many of their side effects, but this good quality is offset by many potentially serious medication interactions. It can increase the activity of liver enzymes involved in breaking down and eliminating medications from your body, leading to less beneficial effects from those medications. Women taking oral contraceptives with St. John's wort have reported breakthrough and irregular menstrual bleeding. In such cases, another method of birth control should also be used. It has also been implicated in cases of dangerously low levels of medications in transplant patients, leading to organ rejection.

Ginkgo biloba may increase the risk of internal bleeding if you also taking warfarin at the same time, because it stops warfarin from breaking down. This prolongs the action of warfarin. Ginkgo also has its own effect by inhibiting blood clotting. Interactions have also been reported by people taking other blood thinners, such as aspirin.

Ginseng (most varieties) is used to improve well-being, enhance the immune system, and boost energy, among many other uses. It has been shown to decrease blood sugar levels in people with diabetes (type 2). If it is taken together with insulin or oral diabetes medications, ginseng may, without careful monitoring, cause low blood sugar levels.

The above herbal supplement-medication interactions are simply a few examples, and these supplements could interact with other medications not indicated above.

Always consult a health care professional

It is a good idea to talk to your doctor or Shoppers Drug Mart Pharmacist about any herbal supplements you wish to take, no matter what medications you're using or the condition for which you're being treated, especially if you're pregnant, breast-feeding, or planning to have surgery.

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